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ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 5  |  Page : 105

Antimycobacterial activity of medicinal plants against the causative agent of buruli ulcer: Mycobacterium ulcerans


1 Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
2 Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon; Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Ghana
3 Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde I; Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Ghana; Institute of Medical Research and Medicinal Plants Studies, Yaounde, Cameroon
4 Laboratory of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

Date of Web Publication17-Feb-2017

Correspondence Address:
R Keumoe
Antimicrobial and Biocontrol Agents Unit (AMBAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaounde' I, P.O. Box 812, Messa-Yaoundé
Cameroon
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.ijmyco.2016.11.004

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  Abstract 


Objective/background: Buruli ulcer, known as necrotizing skin disease caused by Mycobacterium ulcerans, has emerged as the most prevalent mycobacteriosis after leprosy and tuberculosis. Accordingly, it has been classified by the World Health Organization as a neglected disease with high significance in tropical areas, including Cameroon. So far, the control of the disease relies mainly on the rifampin-streptomycin combination. Despite its efficiency, it has shown considerable issues, including availability and side effects. Therefore, more effective and safer drugs are urgently warranted. For this fact, natural plant-based products have always been of great importance in drug discovery. Therefore, the present study was initiated to assess the antimycobacterial properties of four medicinal plants against M. ulcerans.
Methods: The methanolic and aqueous crude extracts prepared from Ficus binjamina, Ficus elastica, Ficus saussureana, and Terminalia superba were screened against M. ulcerans using the resazurin microtiter assay method. The phytochemical screening of promising extracts was performed to reveal bioactive components that might explain the exhibited activity.
Results: Out of the 24 tested extracts, 11 extracts showed promising activity with minimal inhibitory concentration ranging from 62.5 μg/mL to 250 μg/mL. The phytochemical screening revealed the presence of phenols, flavonoids, tanins, triterpenes, glucosides, and saponins.
Conclusion: The obtained results further strengthened the exploitation of these extracts as potent hits in the treatment of Buruli ulcer. Meanwhile, further studies are required to fully characterize the bioactive compounds.

Keywords: Antimycobacterial activity, Chemical composition, Mycobacterium ulcerans, Plant extract


How to cite this article:
Keumoe R, Nguembou M S, Tsouh F P, Donkeng D V, Dize D, Tchokouaha Y L, Jiatsa M C, Youmsi F R, Ngameni B, Fekam B F. Antimycobacterial activity of medicinal plants against the causative agent of buruli ulcer: Mycobacterium ulcerans. Int J Mycobacteriol 2016;5, Suppl S1:105

How to cite this URL:
Keumoe R, Nguembou M S, Tsouh F P, Donkeng D V, Dize D, Tchokouaha Y L, Jiatsa M C, Youmsi F R, Ngameni B, Fekam B F. Antimycobacterial activity of medicinal plants against the causative agent of buruli ulcer: Mycobacterium ulcerans. Int J Mycobacteriol [serial online] 2016 [cited 2020 Aug 7];5, Suppl S1:105. Available from: http://www.ijmyco.org/text.asp?2016/5/5/105/200361




  Conflicts of interest Top


The authors have no conflicts of interest to declare.





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