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ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 5  |  Page : 59

Multidrug-resistant tuberculosis: The problem and some priorities in controlling it


Public Health Agency of and Karolinska Institute, Stockholm, Sweden

Date of Web Publication17-Feb-2017

Correspondence Address:
Sven Hoffner
Department of Micro-, Tumor and Cell Biology, Karolinska Institute, SE-171 77 Stockholm
Sweden
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.ijmyco.2016.10.031

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  Abstract 


Multidrug-resistant tuberculosis (MDR-TB), and even more severe forms of drug resistance, cause significant problems and costs for national TB control programs and constitutes an increasing public health concern globally. In parts of the former Soviet Union, the prevalence of MDR-TB is as high as 50% and one third of all newly detected TB patients are infected with MDR strains. Such strains transmit and certain MDR-TB clones constitute an important part of the problem, especially in high MDR-TB burden areas. There are several actions that should be given priority to control this situation. A first important step is timely detection of all patients infected with resistant strains, which makes possible prompt change of standard TB chemotherapy to more effective combinations of drugs. This is important both from the public health and clinical perspectives, since it renders the individual patient noninfectious and subsequently cured. Early detection of MDR-TB also allows infection control to be focused where it is most needed. Strengthened infection control measures are crucial for limiting the ongoing spread of resistant TB in hospitals and elsewhere. In addition, a sustainable drug supply must be ensured to guarantee that all patients are initiated on effective treatment and can avoid interruptions due to drug shortages. An extra focus should be put on vulnerable cases, such as immunosuppressed individuals, prisoners, drug addicts, and migrants, in whom TB is generally more frequent and difficult to control than in the normal population. Finally, political support is needed to ensure necessary infrastructures, human and financial resources to effectively control drug resistant TB.

Keywords: Drug resistance, Molecular tests, Rapid diagnosis, Tuberculosi


How to cite this article:
Hoffner S. Multidrug-resistant tuberculosis: The problem and some priorities in controlling it. Int J Mycobacteriol 2016;5, Suppl S1:59

How to cite this URL:
Hoffner S. Multidrug-resistant tuberculosis: The problem and some priorities in controlling it. Int J Mycobacteriol [serial online] 2016 [cited 2020 Aug 11];5, Suppl S1:59. Available from: http://www.ijmyco.org/text.asp?2016/5/5/59/200485




  Conflicts of interest Top


The authors have no conflicts of interest to declare.





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