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ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 5  |  Page : 66

Identifying patients at high risk of tuberculosis recurrence


Pulmonary and Critical Care Medicine, Emory University, 1670 Clairmont Rd, Atlanta, GA 30033, USA

Date of Web Publication17-Feb-2017

Correspondence Address:
Ruxana T Sadikot
Pulmonary and Critical Care Medicine, Emory University, 1670 Clairmont Rd, Atlanta, GA 30033
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.ijmyco.2016.08.017

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  Abstract 


Several studies have been done in relation to recurrence of tuberculosis (TB) following completion of treatment. However, recurrence of TB is still a major problem from a public health perspective in high-burden countries, where no special attention is being given to this issue. Disease recurrence is an important indicator of the efficacy of antituberculosis treatment. The rate of recurrence is highly variable and has been estimated to range from 4.9% to 25%. This variability is not only a reflection of regional epidemiology of recurrence but differences in the definitions used by the TB control programs. In addition to treatment failure related to medication adherence, there are several key host factors that are associated with high rates of recurrence. The widely recognized host factors independent of treatment program that predispose to TB recurrence include: malnutrition; human immunodeficiency virus; substance abuse including tobacco use; comorbidity such as diabetes, renal failure and systemic diseases, especially immunosuppressive states; and environmental exposure such as silicosis. With improved understanding of the human genome, proteome, and metabolome, additional host-specific factors that predispose to recurrence are being discovered. Information on temporal and geographical trends of TB cases as well as genotyping might provide further information to enable us to fully understand TB recurrence and discriminate between reactivation and new infection. The recently launched World Health Organization End TB Strategy emphasizes the importance of integrated, patient-centered TB care. Continued improvement in diagnosis, treatment approaches, and defining host-specific factors are needed to fully understand the clinical epidemiological and social determinants of TB recurrence.

Keywords: TB, Recurrence, Host factors


How to cite this article:
Sadikot RT. Identifying patients at high risk of tuberculosis recurrence. Int J Mycobacteriol 2016;5, Suppl S1:66

How to cite this URL:
Sadikot RT. Identifying patients at high risk of tuberculosis recurrence. Int J Mycobacteriol [serial online] 2016 [cited 2018 Sep 26];5, Suppl S1:66. Available from: http://www.ijmyco.org/text.asp?2016/5/5/66/200490




  Conflicts of interest Top


None.





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