• Users Online: 1006
  • Home
  • Print this page
  • Email this page
ORIGINAL RESEARCH ARTICLE
Year : 2017  |  Volume : 6  |  Issue : 1  |  Page : 27-33

Utility of QuantiFERON tuberculosis gold-in-tube test for detecting latent tuberculosis infection among close household contacts of confirmed tuberculosis patients in Accra, Ghana


1 Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana, UK
2 Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana, UK
3 Department of Infectious Diseases and Tropical Medicine, London School of Hygiene and Tropical Medicine, London, UK

Correspondence Address:
Gloria Ivy Mensah
Department of Bacteriology, Noguchi Memorial Institute for Medical Research, P.O. Box LG 581, Legon, Accra
UK
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2212-5531.201891

Rights and Permissions

Objective/Background: Introduction of the interferon gamma (IFN-γ) release assays with their higher sensitivity and specificity over the traditional tuberculin skin test has improved testing for latent tuberculosis infection (LTBI). None of the IFN-γ release assays has ever been used to screen for LTBI in Ghana. This study set out to determine the utility of the QuantiFERON TB Gold-in-Tube (QFT-GIT) test for the diagnosis of LTBI among close household contacts of newly diagnosed sputum smear-positive tuberculosis (TB) patents in Accra, Ghana, and the associated risk factors for a positive QFT-GIT test. Materials and Methods: Close household contacts of newly diagnosed sputum smear-positive patients receiving anti-TB therapy from three hospitals in Accra were recruited, after providing written informed consent, between April 2012 and December 2014. In addition to demographic details, 2 mL of blood was collected from all participants for the QFT-GIT test for LTBI diagnosis. Results: Out of 112 eligible consenting participants, the QFT-GIT test was performed for 100 participants. The prevalence of LTBI (QFT-GIT positive) was 65%, with 32% being QFT-GIT negative and 3% indeterminate results. Contacts aged >15 years were more likely to be QFT-GIT positive than those aged >15 years, regardless of their Bacillus Calmette–Guerin status. There was significantly higher QFT-GIT test positivity in adult contacts who were parents, siblings, or spouses to index cases than in child contacts (P = 0.0016, P = 0.04, and P = 0.0003, respectively). Conclusion: The QFT-GIT test will be a useful tool for screening of TB contacts for LTBI in Ghana.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2054    
    Printed62    
    Emailed1    
    PDF Downloaded321    
    Comments [Add]    
    Cited by others 1    

Recommend this journal