|Year : 2018 | Volume
| Issue : 3 | Page : 288-291
Various cutaneous tuberculosis with rare clinical manifestations: A case series
Hendra Gunawan, Pati Aji Achdiat, Reti Hindritiani, Erika Dewi Essary, Lulu Dwiarti Ningtias, Elfrida Putri Siregar, Putri Reno Sori, Dia Febrina
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia
|Date of Web Publication||6-Sep-2018|
Dr. Hendra Gunawan
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Bandung, West Java
Source of Support: None, Conflict of Interest: None
Cutaneous tuberculosis (TB) has several clinical manifestations. The most common forms include cervical scrofuloderma and plaque type of lupus vulgaris (LV), otherwise the rare cases including inguinal scrofuloderma, ulcerative LV, and acute miliary TB. The highlight of this case series was to report various rare clinical manifestations of cutaneous TB.
Keywords: Acute miliary tuberculosis, cutaneous tuberculosis, lupus vulgaris, scrofuloderma
|How to cite this article:|
Gunawan H, Achdiat PA, Hindritiani R, Essary ED, Ningtias LD, Siregar EP, Sori PR, Febrina D. Various cutaneous tuberculosis with rare clinical manifestations: A case series. Int J Mycobacteriol 2018;7:288-91
|How to cite this URL:|
Gunawan H, Achdiat PA, Hindritiani R, Essary ED, Ningtias LD, Siregar EP, Sori PR, Febrina D. Various cutaneous tuberculosis with rare clinical manifestations: A case series. Int J Mycobacteriol [serial online] 2018 [cited 2020 Apr 10];7:288-91. Available from: http://www.ijmyco.org/text.asp?2018/7/3/288/240690
| Introduction|| |
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis that affects various organs. One of the most infected organs is lungs., The number of extrapulmonary TB reaches up to 14%, and 1%–2% are cutaneous TB., Cutaneous TB is frequently found worldwide, especially in tropical countries.
Clinical manifestation of cutaneous TB is varied and causes difficulties to diagnose. Scrofuloderma is the most common form of cutaneous TB, often affects the supraclavicular, axilla, and both sides of the neck. The other common form of cutaneous TB is plaque type of lupus vulgaris (LV). The rare presentation of cutaneous TB is including inguinal scrofuloderma, ulcerative type of LV, and acute miliary cutaneous TB.,, The aim of this case series was to report several rare clinical manifestations of cutaneous TB.
| Case Reports|| |
A 55-year-old-male complained of a discharging sinus on the left groin for the last month. For 15 months before admission, the lesions appeared as papules that progressed to nodules and leading to draining sinuses. Some of the lesions healing with scars formation. Patient admitted a history of weight loss within the past 3 months. Physical examination revealed a discharging sinus with an enlargement of an inguinal lymph node on the left inguinal region, accompanied with scars and fistules [Figure 1]a, [Figure 1]b, [Figure 1]c. The bacteriological examination of pus showed acid-fast bacilli (AFB) [Figure 1]d. The polymerase chain reaction (PCR) test for M. tuberculosis was negative. The histopathological examination revealed granulomas consisting of inflammatory cells and Langhans cells, which supported the diagnosis of scrofuloderma [Figure 1]e. The patient was treated with anti-TB drugs Category 1 World Health Organization. Clinical improvement was observed after 9 weeks of treatment.
|Figure 1: (a and b) Discharging sinus on the left inguinal region. (c) Scars and fistules after 9 weeks of treatment. (d) Positive acid-fast bacilli from discharge. (e) The pathologic features reveal granulomatous reaction consisting of inflammatory cells and Langhans cells (H and E, ×1000)|
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A 20-year-old-male on the 4th-month anti-TB drugs Category 1 treatment for tuberculous lymphadenitis presented with a painless ulcer on the right thigh. Initially, the skin lesion appeared as a nontender nodule for the past 3 weeks. It became enlarged and ruptured forming an ulcer that produced pus. There was a history of weight loss within 2 months. On physical examination, an ulcer about 3 cm × 4 cm in size with granulation tissue based was found [Figure 2]a and [Figure 2]b. The bacteriological examination showed AFB [Figure 2]c, while the PCR test for M. tuberculosis was positive. From the histopathological examination, the epidermis demonstrated erosive, ulcerative, and hyperplasia; whereas the dermis showed granulomas consisting of epithelioid cells, lymphocytes, and Langhans cells, with caseous necrosis [Figure 2]d, [Figure 2]e, [Figure 2]f. These results are consistent with the diagnosis of ulcerative LV. The anti-TB drugs Category 1 were continued, and the skin lesion was markedly improved on the 22nd day of observation.
|Figure 2: (a and b) An ulcer with granulation tissue based on the right thigh. (c) The bacteriological examination shows acid-fast bacilli feature. The histopathological examination shows (d) granulomatous reaction contained epithelioid cells, lymphocytes, and (e) Langhans cells, with (f) caseous necrosis features in the dermis (H and E, ×100, ×500, ×1000)|
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A 37-year-old-male presented with erythematous papules without itch on almost entire part of the body for 2 weeks before admission. In 2006, the patient was diagnosed with acquired immunodeficiency syndrome (AIDS). He stopped antiretroviral medications since 2015. The patient suffered from cough, intermittent fever, malaise, and excessive sweating. On physical examination, the patient was underweight with pale complexion. There were multiple, discrete pinhead-sized papules with central crust on almost entire body surface [Figure 3]a, [Figure 3]b, [Figure 3]c. Sputum examination and skin scrapping from the skin lesion on the right arm were positive for AFB [Figure 3]d. Chest radiograph showed upper lobes consolidation [Figure 3]e. Therefore, the patient was diagnosed with pulmonary and acute cutaneous miliary TB and treated with anti-TB drugs Category 1. Clinical improvement was obtained on day 43rd observation.
|Figure 3: (a-c) Pinhead-sized erythematous papules with central crusts on almost entire body surface. (d) The bacteriological examination from the lesion on the right arm is positive for acid-fast bacilli. (e) Chest radiograph shows upper lobes consolidation|
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| Discussion|| |
Cutaneous TB was frequently found especially on developing  and tropical countries. It has various clinical manifestations including LV, scrofuloderma, TB verrucosa cutis, orificial TB, tuberculous gumma, tuberculous chancre, and acute cutaneous miliary TB.
The diagnosis of cutaneous TB was established based on absolute and relative criteria. The absolute criteria consist of finding of M. tuberculosis from tissue culture,, inoculation on guinea pig, or positive result on PCR. The relative criteria are based on history taking and clinical manifestations which supported for the diagnosis of cutaneous TB, active TB found on other organs, finding of AFB on lesions, finding of tuberculous granuloma on histopathological examination, positive tuberculin test, and responsiveness toward anti-TB medications.
Scrofuloderma occurs due to the spread of infection from structures beneath the skin, especially lymph nodes. The clinical manifestation of scrofuloderma is initially a firm, well-defined border, mobile, and asymptomatic subcutaneous nodule. The nodule will enlarge and soften, after several months. Therefore, it will rupture and forming ulcer and sinus. Furthermore, a fistule which secreted caseous material was found. Spontaneous involution of the lesions might happen, leaving behind keloid-like scar and skin atrophy. The predilection of scrofuloderma is mostly on the neck, axilla, and supraclavicular., Otherwise, less often on inguinal region. The patient on Case 1 had an initial erythematous nodule on the left inguinal which was neither pruritic nor tender, mobile, and had sinus on the surface. Pus emerged from the sinus when pressed. Scar tissues were also found around the lesion. The clinical manifestation of this case was consistent with the diagnosis of scrofuloderma.
Lupus vulgaris is one of the clinical manifestations of cutaneous TB which commonly found in patients who are sensitized to M. tuberculosis. LV has five major clinical variations including plaque, hypertrophic or vegetation, tumor-like, papular or nodular, and ulcerative types., Based on a study in India, ulcerative was the least common (14.2%) type of LV. On ulcerative LV, the ulcer is the main type of lesion. The predilection sites for LV are the face, neck, lower arms, chest, trunk, and leg., In Case 2, the LV occurred on a patient who was on 4th-month TB treatment for tuberculous lymphadenitis. Initially, there was a nontender nodule on the right thigh, which enlarged and ruptured forming an ulcer that produced pus. The clinical manifestation of Case 2 supported the diagnosis of the ulcerative type of LV.
Acute cutaneous miliary TB is cutaneous TB that occurred due to hematogenous spread of TB in immunocompromised patients, for example, in AIDS patients., The characteristics of this type of cutaneous TB are pinhead sized  to 6 mm sized in diameters of erythematous macules and papules. Vesicles or pustules would form on the center of the lesions, which would rupture and dry forming crusts. When the crusts are lifted, it will leave an umbilicated lesion behind. The skin lesions might appear all over the body. However, it was more commonly found on the trunk, thigh, genitalia, buttocks, and extensor extremities. The skin lesions are neither pruritic nor painful; however, commonly accompanied with constitutional symptoms such as fever, malaise, anorexia, and weight loss. All those signs and symptoms fitted for Case 3.
There are several examinations to support the diagnosis of cutaneous TB. Bacteriological examination for AFB using Ziehl–Neelsen staining of the skin lesion is an important additional examination to diagnose cutaneous TB. AFB was found in all cases of this case series. Cutaneous TB might vary in histopathological appearance; however, in general, it shows granulomas consisting of epithelioid, mononuclear, plasma, and Langhans cells, with or without caseation necrosis., On scrofuloderma, the granulomas are less well formed. Kumar et al. reported that 47.5% of scrofuloderma patients had classic histopathological examination result, whereas the rest 52.5% of patients had a nonspecific result. On LV, the epidermis might appear hyperplastic, atrophic, or ulcerative. Multiple, tuberculoid granuloma  with caseous necrosis might be found on the superficial dermis of LV., On initial lesion of acute miliary cutaneous TB, focal necrosis and abscess were found, with many AFB scattered around nonspecific inflammatory cells.
The histopathological examination of Case 1 revealed a granuloma which consisted of inflammatory and Datia Langhans cells. In Case 2, the histopathological examination showed a granulomatous reaction that composed of epithelioid cells, lymphocytes, and Langhans cells, with caseous necrosis area. In Case 3, the histopathological examination cannot be done due to low hemoglobin level of the patient.
PCR might help establishing the diagnosis of several types of cutaneous TB. PCR procedure is increasingly recognized to detect the deoxyribonucleic acid of M. tuberculosis on skin specimen. Negative PCR result is not strong enough to eliminate the diagnosis of cutaneous TB; hence, the diagnosis should never be established by PCR examination alone. In this case series, PCR was done for Case 1 and Case 2; however, the positive result for M. tuberculosis is only showed on Case 2.
The treatment of TB in Indonesia follows the guidelines from the Ministry of Health, which divided into Category I and II. Category I anti-TB drugs are considered to new TB patients with positive AFB, pulmonary TB patients with negative AFB but positive radiograph examination, and extrapulmonary TB. This Category 1 consists of a 2-month intensive phase with multiple drugs (rifampicin, isoniazid, ethambutol, and pyrazinamide) and 4-month continuation phase with two drugs (rifampicin and isoniazid)., In our cases, all the patients were treated with anti-TB drugs Category 1 and gave good results.
| Conclusion|| |
The cutaneous TB has various clinical manifestations. Some of the cases are uncommon, and it makes difficulties to diagnose. Therefore, the clinicians should recognize all types of cutaneous TB. Hence, therapy could be started immediately, and the morbidity could be reduced.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Sethi A. Tuberculosis and infections with atypical mycobacteria. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, editors. Fitzpatrick's Dermatology in General Medicine. 8th
ed. New York: McGraw-Hill; 2012. p. 3164-89.
Santos JB, Figueiredo AR, Ferraz CE, Oliveira MH, Silva PG, Medeiros VL, et al.
Cutaneous tuberculosis: Epidemiologic, etiopathogenic and clinical aspects – Part I. An Bras Dermatol 2014;89:219-28.
Bravo FG, Gotuzzo E. Cutaneous tuberculosis. Clin Dermatol 2007;25:173-80.
Saritha M, Parveen BA, Anandan V, Priyavathani MR, Tharini KG. Atypical forms of lupus vulgaris – A case series. Int J Dermatol 2009;48:150-3.
Ho SC. Cutaneous tuberculosis: Clinical features, diagnosis, and management. HK Dermatol Venereol Bull 2003;11:130-8.
Pai VV, Naveen KN, Athanikar SB, Dinesh US, Divyashree A, Gupta G, et al.
A clinico-histopathological study of lupus vulgaris: A 3 year experience at a tertiary care centre. Indian Dermatol Online J 2014;5:461-5. [Full text]
Jain SK, Mehta P, Gupta S, Kumar R. A pediatric case of disseminated mutilating lupus vulgaris: A disgrace for society. Indian J Pediatr Dermatol 2016;17:148-50.
Vyas S, Umashankar N, Kothari N, Vyas V. Bilateral inguinal lymphadenopathy presenting as tuberculosis in a case of carcinoma rectum. Int J Mycobacteriol 2017;6:410-1.
] [Full text]
Padmavathy L, Rao LL, Ethirajan N, Krishnaswami B. Ulcerative lupus vulgaris of face: An uncommon presentation in India. Indian J Tuberc 2007;54:52-4.
Barbagallo J, Tager P, Ingleton R, Hirsch RJ, Weinberg JM. Cutaneous tuberculosis: Diagnosis and treatment. Am J Clin Dermatol 2002;3:319-28.
Yates VM. Mycobacterial infections. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology. 8th
ed. Oxford: Blackwell Science Ltd.; 2010. p. 31.10-19.
Rahman MH, Ansari NP, Hadiuzzaman, Nipa NI. Lupus vulgaris on the buttock mimicking tinea corporis. J Pak Assoc Dermatol 2011;21:295-7.
Manapajon A, Jiamton S, Aumcharoen V. Acute tuberculosis cutis miliaris disseminata in a patient with acquired immune deficiency syndrome. Siriraj Med J 2013;65:55-7.
Silva MR, Castro MC. Mycobacterial infections. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd
ed. Spanyol: Mosby Elsevier; 2008. p. 1107-25.
Regnier S, Ouagari Z, Perez ZL, Veziris N, Bricaire F, Caumes E. Cutaneous miliary tuberculosis in a patient infected with human immunode ciency virus: Case report and literature review. Clin Exp Dermatol 2009;34:690-2.
Schermer DR, Simpson CG, Haserick JR, Van Ordstrand HS. Tuberculosis cutis miliaris acuta generalisata. Report of a case in an adult and review of the literature. Arch Dermatol 1969;99:64-9.
Wang H, Wu Q, Lin L, Cui P. Cutaneous tuberculosis: A diagnostic and therapeutic study of 20 cases. J Dermatolog Treat 2011;22:310-4.
Sacchidanand S, Sharavana S, Mallikarjun M, Nataraja HV. Giant lupus vulgaris: A rare presentation. Indian Dermatol Online J 2012;3:34-6.
] [Full text]
Kumar B, Rai R, Kaur I, Sahoo B, Muralidhar S, Radotra BD, et al.
Childhood cutaneous tuberculosis: A study over 25 years from Northern India. Int J Dermatol 2001;40:26-32.
Weedon D. Bacterial and rickettsial infections. In: Weedon's Skin Pathology. 3rd
ed. London: Churchil Livingstone Elsevier; 2010. p. 558-9.
Senturk N, Sahin S, Kocagoz T. Polymerase chain reaction in cutaneous tuberculosis: Is it a reliable diagnostic method in paraffin-embedded tissues? Int J Dermatol 2002;41:863-6.
Abdalla CM, de Oliveira ZN, Sotto MN, Leite KR, Canavez FC, de Carvalho CM. Polymerase chain reaction compared to other laboratory findings and to clinical evaluation in the diagnosis of cutaneous tuberculosis and atypical mycobacteria skin infection. Int J Dermatol 2009;48:27-35.
Departemen Kesehatan Republik Indonesia. Pedoman Nasional Penanggulangan Tuberkulosis. 2nd
ed. Jakarta: Departemen Kesehatan Republik Indonesia; 2010. p. 13-33.
Handog EB, Gabriel TG, Pineda RT. Management of cutaneous tuberculosis. Dermatol Ther 2008;21:154-61.
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