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Year : 2019  |  Volume : 8  |  Issue : 3  |  Page : 305-308

Multidrug resistance as a cause of steroid-nonresponsive downgrading type I reaction in Hansen's disease

1 Department of Dermatology, STD and Leprosy, Dr. RML Hospital and PGIMER, New Delhi, India
2 Department of Pathology, Dr. RML Hospital and PGIMER, New Delhi, India
3 Department of Molecular Biology, Stanley Browne Laboratory, TLM Community Hospital, New Delhi, India

Correspondence Address:
Dr Kabir Sardana
Room 108, OPD Building, Dr. Ram Manohar Lohia Hospital and PGIMER, Baba Kharak Singh Marg, New Delhi - 110 001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmy.ijmy_121_19

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While Type 1 reaction in Hansen's disease is commonly encountered, the triggers and reasons for its persistence are not well understood even though the immunological milieu and cytokine interplay have been studied. Herein, we present a case of Type 1 downgrading reaction in which multidrug resistance was the probable cause of steroid-nonresponsiveness and which responded promptly on starting alternate antileprosy treatment.

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