The International Journal of Mycobacteriology

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 8  |  Issue : 2  |  Page : 113--117

Risk factors associated with unsuppressed viral load in HIV-1 infected patients at the first antiretroviral therapy in Morocco


Titou Hicham1, Elkassimi Ilyas2, Hanafi Tarik1, Baba Noureddine1, Boudi Omar1, Frikh Rachid1, Hjira Naoufal1, Boui Mohammed1 
1 Department of Dermatology and Venereology, Military Hospital Mohammed V, Mohammed V University, Rabat, Morocco
2 Department of Internal Medicine, Military Hospital Mohammed V, Mohammed V University, Rabat, Morocco

Correspondence Address:
Titou Hicham
Department of Dermatology and Venereology, Military Hospital Mohammed V, Hay Ryad, 10100 Rabat
Morocco

Background: Nonsuppression of viral load (VL) in HIV-infected patients on antiretroviral therapy (ART) is associated with increased HIV transmission and poor survival. The objective of this work was to evaluate the factors associated with the unsuppressed VL (VL >400 copies/ml) in HIV-1-infected patients after 6 months of the first-line ART. Methods: This was a retrospective cohort study of 181 patients living with HIV-1 on ART in Dermatology and Venereology Department of Mohamed V Military Teaching Hospital of Rabat, during the period between January 1, 2007, and January 1, 2017. Associated factors were identified through a logistic regression model. Results: Of the 181 patients, 76% were men. At inclusion, the median age was 35 years. Five variables (male sex, initial fasting glucose >1.1 g/l, alcoholism, smoking, and initial VL >10,000 copies/ml) were significantly associated (P < 0.05) with unsuppressed VL. In multivariate analysis, smoking (relative risk [RR]: 4.27, 95% confidence interval [CI]: 1.67–10.89) and initial VL >10,000 (RR: 9.78, 95% CI: 2.40–39.73) were associated independently with unsuppressed VL. Conclusion: Approximately 83% of the patients in the cohort had been able to suppress VL after 6 months of the first-line ART. Smoking and high initial VL were independent risk factors of unsuppressed VL. This work highlights the importance of developing and evaluating targeted interventions for patients at risk of unsuppressed VL on ART.


How to cite this article:
Hicham T, Ilyas E, Tarik H, Noureddine B, Omar B, Rachid F, Naoufal H, Mohammed B. Risk factors associated with unsuppressed viral load in HIV-1 infected patients at the first antiretroviral therapy in Morocco.Int J Mycobacteriol 2019;8:113-117


How to cite this URL:
Hicham T, Ilyas E, Tarik H, Noureddine B, Omar B, Rachid F, Naoufal H, Mohammed B. Risk factors associated with unsuppressed viral load in HIV-1 infected patients at the first antiretroviral therapy in Morocco. Int J Mycobacteriol [serial online] 2019 [cited 2019 Jul 15 ];8:113-117
Available from: http://www.ijmyco.org/article.asp?issn=2212-5531;year=2019;volume=8;issue=2;spage=113;epage=117;aulast=Hicham;type=0