• Users Online: 1056
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 2  |  Page : 143-147

Latent tuberculosis infection among patients with coronary artery stenosis: A case–Control study


1 Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Asyut, Egypt
2 Department of Cardiology, Faculty of Medicine, Assiut University, Asyut, Egypt
3 Department of Chest Diseases, Faculty of Medicine, Assiut University, Asyut, Egypt
4 Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Asyut, Egypt
5 Department of Diagnostic Radiology, Faculty of Medicine, Assiut University, Asyut, Egypt
6 Department of Biochemistry, Faculty of Medicine, Assiut University, Asyut, Egypt

Correspondence Address:
Ahmad Farooq Alsayed Hasanain
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Asyut
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmy.ijmy_34_18

Rights and Permissions

Background: The activation of the cell-mediated immune responses by Mycobacterium tuberculosis can promote atherogenesis. Aims: The aim of this study is to determine the frequency of latent tuberculosis infection (LTBI) among patients with coronary artery stenosis (CAS) and to explore the association between LTBI and development of CAS. We conducted a case–control study which included 183 patients′ who underwent percutaneous coronary angiography (121 patients with CAS and 62 patients without as a control group). Methods: For all the study population, clinical evaluation, tuberculin skin test (TST), imaging studies (including chest radiography and echocardiography), laboratory investigations, and electrocardiography were carried out. Only for the patients with positive TST, QuantiFERON-TB Gold test was performed. Predictors of CAS were identified using univariate analyses (Yates' corrected Chi-square test or Fischer's exact test) followed by multivariate analysis (binary logistic regression). Results: Among 29.5% of the study population, LTBI was detected, and among patients with CAS, 56.2% of patients had advanced CAS. After multivariate analysis, it was found that metabolic syndrome (MS) (odds ratio [OR] 3.6, 95% confidence interval [CI] 1.5–22.6, P = 0.022) and LTBI (OR 2.5, 95% CI 1.2–17.3, P = 0.018) were the predictors of CAS among the study population, while only diabetes mellitus (DM) (OR 1.9, 95% CI 1.1–11.7, P = 0.031) was the predictor of advanced CAS. Conclusion: LTBI is associated with the development of CAS. In addition, MS is associated with CAS, while its related disorder, DM, is associated with advanced CAS.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2279    
    Printed78    
    Emailed0    
    PDF Downloaded263    
    Comments [Add]    
    Cited by others 3    

Recommend this journal