|LETTER TO EDITOR
|Year : 2022 | Volume
| Issue : 2 | Page : 225
Genetic polymorphism of toll-like receptors in HIV-I infected patient and tuberculosis Co-Infection
Rujittika Mungmunpuntipantip1, Viroj Wiwanitkit2
1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India
|Date of Submission||18-Mar-2022|
|Date of Acceptance||28-Mar-2022|
|Date of Web Publication||14-Jun-2022|
|Date of Print Publicaton||14-Jun-2022|
Private Academic Consultant, 26 Bangkok 112 Bangkok 103300
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Mungmunpuntipantip R, Wiwanitkit V. Genetic polymorphism of toll-like receptors in HIV-I infected patient and tuberculosis Co-Infection. Int J Mycobacteriol 2022;11:225
|How to cite this URL:|
Mungmunpuntipantip R, Wiwanitkit V. Genetic polymorphism of toll-like receptors in HIV-I infected patient and tuberculosis Co-Infection. Int J Mycobacteriol [serial online] 2022 [cited 2022 Jul 6];11:225. Available from: https://www.ijmyco.org/text.asp?2022/11/2/225/347515
We would like to share ideas on the publication “Genetic polymorphism of toll-like receptors in HIV-I infected patients with and without tuberculosis co-infection.” According to Kaushik et al., the Asp299Gly polymorphism in the TLR4 gene is linked to higher susceptibility to active tuberculosis (TB) in HIV-positive patients. Increased frequency of the “A” allele in the TLR9 gene was also discovered at the time of active TB development in ART-naive HIV+ patients who acquired active TB on follow-up, according to Kaushik et al.
The Asp299Gly polymorphism in the TLR4 gene, we agree, could have clinical implications. On the other hand, various complicating variables should be considered. In addition to the Asp299Gly polymorphism in the TLR4 gene, there are other genetic variants that may be connected to TB co-infection in HIV. These polymorphisms include the rs12722 COL5A1 and rs3751143 P2X7 polymorphisms., More research is needed to establish if those variables have a confounding effect.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Kaushik G, Vashishtha R, Tripathi H, Yadav RN. Genetic polymorphism of toll-like receptors in HIV-I infected patients with and without tuberculosis co-infection. Int J Mycobacteriol 2022;11:95-102.
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Keikha M, Karbalaei M. P2X7 polymorphism (rs3751143) and its reliability as a diagnostic biomarker for tuberculosis: A systematic review and meta-analysis. Indian J Tuberc 2022;69:85-9.
Zhetkenev S, Khassan A, Khamzina A, Issanov A, Crape B, Akilzhanova A, et al.
Association of rs12722 COL5A1 with pulmonary tuberculosis: A preliminary case-control study in a Kazakhstani population. Mol Biol Rep 2021;48:691-9.