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 Table of Contents  
Year : 2022  |  Volume : 11  |  Issue : 3  |  Page : 341-342

Tumor necrotic factor pathway, monkeypox, and tuberculosis: Correspondence

1 Private Academic Consultant, Bangkok, Thailand
2 Department of Biological Science, Joseph Ayobaalola University, Ikeji-Arakeji, Nigeria; Department of Community Medicine, Dr. D. Y. Patil University, Pune, Maharashtra, India; Department of Medical Science, Faculty of Medicine, University of Nis, Nis, Serbia

Date of Submission08-Jun-2022
Date of Decision09-Aug-2022
Date of Acceptance09-Aug-2022
Date of Web Publication12-Sep-2022

Correspondence Address:
Rujittika Mungmunpuntipantip
Private Academic Consultant, 111 Bangkok 112 Bangkok 103300, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmy.ijmy_129_22

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How to cite this article:
Mungmunpuntipantip R, Wiwanitkit V. Tumor necrotic factor pathway, monkeypox, and tuberculosis: Correspondence. Int J Mycobacteriol 2022;11:341-2

How to cite this URL:
Mungmunpuntipantip R, Wiwanitkit V. Tumor necrotic factor pathway, monkeypox, and tuberculosis: Correspondence. Int J Mycobacteriol [serial online] 2022 [cited 2022 Nov 26];11:341-2. Available from: https://www.ijmyco.org/text.asp?2022/11/3/341/355920

Dear Editor,

In modern clinical medicine, novel zoonotic infections are a major source of worry.[1] A serious public health issue has been created by the spread of monkeypox throughout Europe.[2] A unusual form of the pox called “monkeypox” has likely resurfaced due to zoonosis.[1] A serious public health problem has been created by the spread of monkeypox throughout Europe, America, and Asia.[2] Uncommon monkeypox has returned, most likely as a result of zoonosis. It is being thought about if human-to-human transfer is a possibility. As the number of cases reported in various nations rises, the medical community is alarmed, and meticulous planning is needed to prepare for a potential major outbreak. We must act quickly and decisively to undertake a thorough investigation and put essential counteracting in place.[2] Monkeypox infection is traditionally endemic throughout Western Africa, particularly in Nigeria. Tuberculosis is a major local public health hazard in the same area. However, there has never been a report of coinfection or a contemporaneous outbreak in this location. Using bioinformatic pathophysiological pathway analysis, the authors investigate the pathophysiological pathways of both monkeypox and tuberculosis. The most typical path is being examined. This is the standard technique used in previous pathophysiological pathway analysis research to understand the pathophysiological process of virus infection.[3] Based on pathway analysis, the tumor necrotic factor pathway was found as a common pathway in both disorders. Monkeypox can impair NK cell degranulation and inhibit interferon- and tumor necrosis factor-alpha release via the tumor necrosis factor receptor pathway.[4] Whereas, antitumor necrotic factor alpha is the new current recommended strategy for tuberculosis treatment.[5] [Figure 1] is a schematic of a frequent pathway. The pathophysiological process of monkeypox has a reversible effect on tuberculosis. The new findings imply that tuberculosis and monkeypox share a natural competitive pathophysiological pathway, which could explain the two important local infectious diseases' unusual co-occurrence in endemic African regions.
Figure 1: Common pathway analysis at tumor necrotic factor pathway between tuberculosis 80 and monkeypox

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There are no conflicts of interest.

  References Top

Wiwanitkit S, Wiwanitkit V. Atypical zoonotic pox: Acute merging illness that can be easily forgotten. J Acute Dis 2018;7:88-9.  Back to cited text no. 1
  [Full text]  
Mungmunpuntipantip V, Wiwanitkit V. Re-emerging monkeypox: An old disease to be monitored. BMJ Rapid Response Accessible onlineat https://www.bmj.com/content/377/bmj.o1239/rr-1 22. [Last accessed on 21 May 20].  Back to cited text no. 2
Yasri S, Wiwanitkit V. Usefulness of ginseng in management of dengue: A bioinformatics pathway interrelationship analysis. Int J Physiol Pathophysiol Pharmacol 2022;14:114-7.  Back to cited text no. 3
Song H, Josleyn N, Janosko K, Skinner J, Reeves RK, Cohen M, et al. Monkeypox virus infection of rhesus macaques induces massive expansion of natural killer cells but suppresses natural killer cell functions. PLoS One 2013;8:e77804.  Back to cited text no. 4
Godfrey MS, Friedman LN. Tuberculosis and biologic therapies: Anti-tumor 75 necrosis factor-α and beyond. Clin Chest Med 2019;40:721-39.  Back to cited text no. 5


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