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ORIGINAL ARTICLE
Year : 2022  |  Volume : 11  |  Issue : 4  |  Page : 364-370

Tuberculin test versus interferon gamma release assay in pregnant women with household contacts of tuberculosis patients


1 Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University Hospital, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia
2 Postgraduate Program, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia
3 Department of Clinical Microbiology, Faculty of Medicine, Hasanuddin University Hospital, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia

Correspondence Address:
Maisuri Tadjuddin Chalid
Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University Hospital, Universitas Hasanuddin, Perintis Kemerdekaan Street Km. 10, Tamalanrea, Makassar 90245, South Sulawesi
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmy.ijmy_112_22

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Background: Pregnant women who live in tuberculosis (TB)-affected households are more likely to develop latent TB infection (LTBI), which often escapes treatment. This study aims to determine if Interferon-gamma release (IGRA) is reliable in screening for LTBI in pregnant women, compare to the tuberculin skin test (TST). Methods: It was a cross-sectional study that involved 60 pregnant women with TB contact history as a proxy for LTBI and 30 pregnant women without contact history. Latent TB was detected using the TST 5 tuberculin units and IGRA using the QuantiFERON Gold Plus TB Test kit (QFT-Plus). The sensitivity and specificity of the two diagnostic methods and the agreement between them were estimated using SPSS version 20.0. Results: The sensitivity 95% (95% confidence interval [CI]: 86.08%–98.96%) and specificity 26.7% (95% CI: 12.28%–45.89%) of TST were compared to that of the IGRA with 60% (95% CI: 46.54%–72.44%) and 73.3% (95% CI: 54.11%–87.72%) sensitivity and specificity, respectively in detecting LTBI in pregnancy. Although there was a significant difference (P < 0.05) between TST and IGRA, the agreement was fair (kappa 0.39; 95% CI: 0.24–0.45). Conclusion: TST assay is more sensitive than IGRA; however, the specificity of IGRA was superior to the TST method. In this study, a fair agreement of TST and IGRA was observed for detecting latent TB infection in pregnant women with household contact with TB patients.


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