The International Journal of Mycobacteriology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 9  |  Issue : 4  |  Page : 363--367

Prevalence of latent tuberculosis infection in HIV-1-infected children on antiretroviral therapy in Jos, Nigeria


Augustine Odo Ebonyi1, Stephen Oguche1, Beate Kampmann2 
1 Department of Paediatrics, Jos University Teaching Hospital/University of Jos, Jos, Nigeria
2 The Vaccine Centre, London School of Hygiene and Tropical Medicine; Department of Infectious Disease, Faculty of Medicine, Imperial College, London, England, UK

Correspondence Address:
Augustine Odo Ebonyi
Department of Paediatrics, Jos University Teaching Hospital, PMB 2076, Jos
Nigeria

Background: There are few studies investigating the prevalence of latent tuberculosis infection (LTBI) in HIV-1-infected children on antiretroviral therapy (ART), but no data from Nigeria. This study determined the prevalence of LTBI in HIV-1-infected children on ART in our clinic. Knowing the prevalence and thus the burden of LTBI could help improve HIV care by enabling targeted isoniazid (INH) prophylaxis. Method: This observational study was carried out from September 2016 to August 2017 at the pediatric HIV clinic of the Jos University Teaching Hospital among HIV-1-infected children on ART, aged 6 months–15 years. LTBI was diagnosed using an interferon-gamma release assay, the ELISpot test, T-SPOT®.TB assay (Oxford Immunotec, Abingdon, UK) on freshly collected whole blood samples within 2 h. Children with a positive test were treated with INH after first excluding TB by chest X-ray and clinical evaluation. Results: Of the 90 children studied, 4 (4.4%) had LTBI diagnosed by ELISpot. Their median interquartile range (IQR) age was 10.4 years (7.9–12.5), the majority were male (54.4%) and most of them had originally received Bacille Calmette-Guérin (83/89, 93.3%). They had a median CD4 count of 694 cells/μL (472–1045). The median (IQR) CD4 count was higher in LTBI compared to non-LTBI children: 1286 cells/μL (953–1375) versus 683 cells/μL (465–1040), (P = 0.044). Conclusion: Although this study showed a very low prevalence of LTBI in our setting, it was still beneficial to the few children on ART identified with LTBI as it enabled treatment with INH. A larger study will be required to ascertain the actual burden of LTBI in such children in our setting.


How to cite this article:
Ebonyi AO, Oguche S, Kampmann B. Prevalence of latent tuberculosis infection in HIV-1-infected children on antiretroviral therapy in Jos, Nigeria.Int J Mycobacteriol 2020;9:363-367


How to cite this URL:
Ebonyi AO, Oguche S, Kampmann B. Prevalence of latent tuberculosis infection in HIV-1-infected children on antiretroviral therapy in Jos, Nigeria. Int J Mycobacteriol [serial online] 2020 [cited 2021 Jan 22 ];9:363-367
Available from: https://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=4;spage=363;epage=367;aulast=Ebonyi;type=0